Effects of in Utero Exposure to Pfoa and Pfos on Human Semen Quality and Hormone Profile
نویسندگان
چکیده
Anne Vested, Aarhus University Hospital, Denmark Cecilia Hoest Ramlau-Hansen, University of Aarhus, Denmark Sjurdur Frodi Olsen, Statens Serum Institut, Denmark Jens Peter Bonde, Bispebjerg Hospital of Copenhagen University, Denmark Susanne Lund Kristensen, Aarhus University Hospital, Denmark Thorhallur Ingi Halldorsson, University of Iceland, Iceland Georg Becher, Norwegian Institute of Public Health, Norway Line Smaastuen Haug, Norwegian Institute of Public Health, Norway Emil Hagen Ernst, University of Aarhus, Denmark Gunnar Toft, Aarhus University Hospital, Denmark
منابع مشابه
Associations of in Utero Exposure to Perfluorinated Alkyl Acids with Human Semen Quality and Reproductive Hormones in Adult Men
BACKGROUND Perfluorinated alkyl acids (PFAAs), persistent chemicals with unique water-, dirt-, and oil-repellent properties, are suspected of having endocrine-disrupting activity. The PFAA compounds perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) are found globally in humans; because they readily cross the placental barrier, in utero exposure may be a cause for concern. ...
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Background: There is an important evidence that prolonged exposure to several endocrine disrupting chemicals (EDCs). These are persistent materials with unique environmental properties such as intake of contaminated food, water and air, irrespective of proximity to industries, which are suspected to have endocrine disrupting activities. Perflurooctanoic acid (PFOA) and diethylstilbestrol (EDCs)...
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BACKGROUND Perfluoroalkyl acids (PFAAs) are found globally in wildlife and humans and are suspected to act as endocrine disruptors. There are no previous reports of PFAA levels in adult men from Denmark or of a possible association between semen quality and PFAA exposure. OBJECTIVES We investigated possible associations between PFAAs and testicular function. We hypothesized that higher PFAA l...
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Toxic effects following repeated oral exposure includes effects on the liver, gastrointestinal and thyroid hormone effects Hepatotoxicity is the main effect reported in animals exposed to PFOS or PFOA via ingestion A small number of occupational studies have reported an association between exposure to PFOS or PFOA and several forms of cancer. Animals studies suggest that both PFOS and P...
متن کاملIn utero exposure to perfluorooctanoate (PFOA) or perfluorooctane sulfonate (PFOS) did not increase body weight or intestinal tumorigenesis in multiple intestinal neoplasia (Min/+) mice.
We examined whether perfluorooctanoate (PFOA) or perfluorooctane sulfonate (PFOS) had obesogenic effects and if they increased spontaneous intestinal tumorigenesis in the mouse model C57BL/6J-Min/+ (multiple intestinal neoplasia) after in utero exposure. The dams were exposed to PFOA or PFOS (0.01, 0.1 or 3.0mg/kg bw/day) by po gavage on GD1-17. The Min/+ and wild-type offspring were terminated...
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